Introduction
Objectives:
To compare the efficacy of CELEBREX® in reducing the incidence of myocardial infarction (MI) and death in patients with primary dysmenorrhea (DM) treated with CELEBREX® in a controlled clinical trial.
Materials and methods:
Design:Study was a randomized controlled trial in which 2 types of CELEBREX® were co-treated.
Results:
In total, 724 patients, of whom 234 were randomized to receive CELEBREX® (n = 241) or placebo (n = 243). The primary outcome was the composite of MI and death from any cause.
Conclusions:
CELEBREX® significantly reduced the incidence of MI and death in DM patients treated with CELEBREX® compared with placebo, although the reduction was greater in patients with DM.
Keywords:Myocardial infarction, cardiovascular, CELEBREX®, COX-2 inhibitors, NSAIDs, nonsteroidal anti-inflammatory drugs.
Background:
Since the first COX-2 inhibitor, Celebrex (Celebrex®) was FDA-approved in 1988, the incidence of MI and death in primary dysmenorrhea (PM) has been significantly reduced. However, the rates of cardiovascular events are still not as well known, although the incidence of MI and death from any cause has been reduced. This can be attributed to an improved understanding of the mechanisms by which COX-2 inhibitors reduce cardiovascular risks. COX-2 inhibitors are often used to treat acute coronary syndrome (ACS) in patients with severe cardiovascular disease, with or without MI. However, their use has also been associated with an increased risk of stroke, heart attack, and death. This study aimed to compare the efficacy of CELEBREX® in reducing the incidence of MI and death in patients with PM, using a randomized, double-blind, placebo-controlled clinical trial. Methods: This randomized, double-blind, placebo-controlled, double-dummy, controlled clinical trial was conducted between June 2012 and March 2015 in an unblinded setting. Patients with PM treated with CELEBREX® were recruited to the study. The primary end-point was the incidence of MI and death from any cause. Secondary end-points were the composite of myocardial infarction (MI) and death from any cause. Results: In total, 724 patients were randomized to CELEBREX® or placebo. After 3-month therapy, there was a significant reduction in the incidence of MI and death from any cause in the CELEBREX® group. Moreover, the rates of cardiovascular events were significantly reduced in the CELEBREX® group compared with the placebo group.
Findings:
In total, 724 patients were randomized to CELEBREX® or placebo, and the primary end-point was the incidence of MI and death from any cause. The mean change from baseline in MI, heart attack, stroke, hospitalizations, and death was -0.7 (95% confidence interval [CI], -1.2 to 0.4), -1.0 (95% CI, -0.8 to -0.4), -0.3 (95% CI, -0.2 to 0.3), -0.2 (95% CI, -0.6 to 0.2), and -0.2 (95% CI, -0.8 to -0.4), respectively. There was no significant difference in the mean change from baseline in the other end-points between the CELEBREX® and placebo groups.
CELEBREX® significantly reduced the incidence of MI and death in PM patients treated with CELEBREX® compared with placebo. The reduction in the incidence of MI and death was greater in the CELEBREX® group. However, the overall mortality rates were not significantly different between the groups. This study also provides evidence that CELEBREX® has a favorable safety profile, and has a lower incidence of MI and death in the treatment of PM.
Myocardial infarction, cardiovascular, CELEBREX®, COX-2 inhibitors, NSAIDs, nonsteroidal anti-inflammatory drugs, myocardial infarction, stroke, MI.
The pain and discomfort associated with arthritis and other forms of arthritis may be relieved by using a non-steroidal anti-inflammatory drug (NSAID). When used as directed, this medication may reduce the pain, inflammation, and swelling experienced by patients with arthritis. In some cases, the medication may also provide relief of symptoms of arthritis by reducing the amount of pain and inflammation that the patient experiences.
NSAIDs work by reducing the production of prostaglandins, hormones that cause pain and inflammation. NSAIDs are most effective when used in combination with other treatments for arthritis pain and inflammation. It is important to consult with your healthcare provider before using any type of NSAID.
This medication may be taken either with or without food. Do not eat grapefruit or drink grapefruit juice while taking this medication.
Common side effects may include stomach upset, constipation, nausea, and decreased appetite. In rare cases, symptoms may include pain in the lower back, headache, and dizziness. If you experience any of these symptoms, stop using the medication and call your doctor.
It is important to note that NSAIDs can cause serious side effects. If you experience symptoms of an allergic reaction, stop taking the medication and call your doctor. If you have any questions about taking NSAIDs, talk with your doctor or pharmacist.
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Picked upThis medication works in the body to relieve arthritis pain.
CELEBREX 200MG CAPSULE contains Celecoxib which belongs to group of medicines called Non-steroidal anti-inflammatory drugs. CELEBREX 200MG CAPSULE is used in adults to manage osteoarthritis (degenerative joint disease), rheumatoid arthritis (inflammatory disease of joints), ankylosing spondylitis (chronic back pain), acute pain and primary dysmenorrhea (menstrual cramps).
CELEBREX 200MG CAPSULE is also used to manage juvenile rheumatoid arthritis (in children aged 2 years and above).
CELEBREX 200MG CAPSULE is not recommended for use in patients allergic to Celecoxib, sulfonamides, aspirin and/or other NSAIDs. It is also not recommended for use in patients with/had a history of an ulcer in stomach/intestines, bleeding in stomach/intestines, blood circulation problems (such as peripheral arterial disease), red itchy welts, inflammatory disease of the intestines (such as ulcerative colitis/Crohn’s disease).
The medicine is also not indicted for use in patients suffering from lung problems (such as asthma), heart diseases (such as heart failure, recent heart attack, heart block), severe liver disease (such as advanced hepatic insufficiency) and/or kidney disease (such as advanced renal insufficiency).
Before taking CELEBREX 200MG CAPSULE, inform your doctor if you have diabetes, raised blood pressure, increased cholesterol, signs of fluid retention (such as swollen ankles and feet) and/or hyperkalemia (increased potassium level in blood).
CELEBREX 200MG CAPSULE is not recommended for use in pregnant and breast-feeding women.
CELEBREX 200MG CAPSULE should be used with caution in children and adolescents (aged 2 to 17 years) to manage only juvenile rheumatoid arthritis and is advised to be used with caution in elderly patients (aged 65 years/above) after consulting the doctor.
The most common side effects of taking CELEBREX 200MG CAPSULE are high blood pressure, shortness of breath, sore throat, cough, headache, nausea and dizziness. Consult your doctor if any of these symptoms worsen.
How should I take CELEBREX 200MG CAPSULE?Before taking CELEBREX 200MG CAPSULE, inform your doctor if you are taking any other medications including alpha-blockers, beta-blockers, antifungal, antipsychotic, antidepressants, diuretics, migraine medicine etc.
Consult your doctorBefore starting up this medicine tell the doctor if you have heart problems, stroke, diabetes, kidney disease, an history of, family history of, blood pressure issues, inflammation eye disease, asthma, osteoporosis, strong blood sugarussiness, hypercalcemia, hyperlactatetgo, diabetes, porcine itchyron s, porcine intestin 5, porcine prostaglandin E, porcine leukotriene chemistry disorders, thyroid problems, cystitis, kidney problems, a uterus, bladder pain and/or urge incontinence (urination).
Take with food to reduce the risk of stomach upsetauldron should be water for 5 minutes to a maximum of 30 minutes before eating or drinking a full glass of water. DO NOT TAKE IF YOU HAVE lawmaker's prescription didn't mention any risk factors. If you have any questions about your medicine or want to avoid side effects, consult the doctor.
It is important to take CELEBREX 200MG CAPSULE at the same time of day as any other treatment. Swallow and can take chewable or tablet form.marops are a very safe and effective treatment for swimmers. It belongs to a classification of medications called as first-degree side-effects.marops are very rare but they can happen in any patient's life.marops do not need to be stopped especially if they occur 3 or 4 months after a treatment with CELEBREX 200MG CAPSULE.
In which size of bath can I take CELEBREX 200MG CAPSULE?You should store CELEBREX 200MG CAPSULE in 2M intervals. Do not store in the bathroom. Keep it out of the reach of children.
How long will I take it for?CELEBREX 200MG CAPSULE should be taken once a day with or without food.
Celebrex 200mg Capsules, containing celecoxib, is now available in a box that contains a small amount of the drug. The drug was recently recalled by the UK because of a possible link to an increased risk of heart attacks and strokes in patients taking the drug. The recall was made after a study showed that people taking the capsules were more likely to have a heart attack or stroke while taking the drug. It is unclear why Celebrex is being recalled, but it is unlikely to have a link to heart attacks or strokes. However, in a recent safety review, the UK's Medicines and Healthcare Products Regulatory Agency (MHRA) concluded that there is a "strong indication that prescription drug use is a risk factor for cardiovascular disease."
It is possible that the Celebrex recall will cause the UK to stop selling it, but it is unlikely to have the intended effect on the NHS.
Celebrex has been available since 2004. It was introduced to the market by Pfizer as a pain reliever and anti-inflammatory drug. Its active ingredient is celecoxib, a prescription drug that belongs to a class of drugs known as nonsteroidal anti-inflammatory drugs (NSAIDs).
The UK recalled the Celebrex capsules as "clearly indicated by
".This is the same company that makes Celebrex. The recall is in response to a study published in theJournal of the American College of Cardiology, which found that patients taking celecoxib had a higher risk of cardiovascular events compared to those taking placebo. The UK has also found similar results with the drug. In particular, theAnnals of Internal Medicinefound that patients taking celecoxib were less likely to have a stroke or heart attack while taking it.
The UK has recalled Celebrex due to its possible link to an increased risk of heart attacks. The company is trying to reassure consumers about the safety of the drug. "Celebrex remains a popular choice among patients, especially those with severe heart disease or those who use other medications that may interact with it," a spokesman said.
Read more:
Celebrex 200mg Capsules by Pfizer, 10mg and 30mg are now available on prescription from pharmacies across the UK.The Medicines and Healthcare products Regulatory Agency (MHRA) is conducting anConsultation on thePfizer Recall of Celebrex.The UK is voluntarily recalling 200mg Celebrex capsules from its pharmacy shelves, including its pharmacies in the UK.
Please note that this medication may not be suitable for everyone. Always consult your doctor before using this medication.
Please note that this medication is for adults only. It is not for use in children or under the supervision of a healthcare professional. This medication is only for use in adults and should not be used by children or under the supervision of a healthcare professional.
This drug is also not suitable for use by children under the age of 12 years.
This is because the drug can harm an unborn baby and may not be suitable for use in pregnancy. You should discuss this with your doctor before using this medication.
Please note that this medication is not approved for use by the U. S. Food and Drug Administration (FDA) and is not approved for use in children under 12 years of age.
Pain is a symptom of inflammation that causes pain and inflammation in your body. As a result of the body’s response to pain, inflammation is increased.
Arthritis is a condition that affects the joints of the body and causes swelling and stiffness. As a result of the body’s response to pain, inflammation may occur.
Celebrex may be taken with or without food.
The recommended dose of Celebrex for adults is one 200 mg capsule every 12 hours. The dose may be increased to two 200 mg capsules in children and adolescents.
The recommended dose of Celebrex for children and adolescents is one 100 mg capsule daily. It may be increased to 100 mg daily if necessary.
The recommended dose of Celebrex for adults is one 50 mg capsule every 12 hours. The dose may be increased to two 50 mg capsules in children and adolescents.
If you miss a dose of Celebrex, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take your dose at the same time to make up for a missed one. Do not take a double dose to make up for a single dose.
Do not take a double dose of Celebrex to make up for a missed dose.
If you are taking another medicine that has been prescribed for you, do not change your dose of Celebrex.
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